The Two Faces of JanusUnfolded Protein Response - Autophagy in Cell Death and Survival

  1. Marcilla Etxenike, Amaia
Dirigée par:
  1. Pablo Vicente Escribá Ruiz Directeur/trice
  2. Xavier Busquets Xaubet Directeur/trice

Université de défendre: Universitat de les Illes Balears

Fecha de defensa: 30 novembre 2012

Jury:
  1. Jose Manuel González Ros President
  2. José Aurelio Castro Ocón Secrétaire
  3. Rafel Aguiló Espases Rapporteur
  4. Arsenio Fernández López Rapporteur
  5. Luc Leyns Rapporteur

Type: Thèses

Teseo: 334815 DIALNET lock_openRepositoriUIB editor

Résumé

In this thesis, the pharmacological effects of lipid derivatives against glioma and Alzheimer's Disease are studied. The benefits of this type of drugs, which are based on the lipid membrane therapy, are associated with the modulation of the composition and physicochemical properties of membranes. 2-Hydroxyoleic acid (2OHOA) is a potent antitumor drug designed to regulate membrane lipid composition and structure and the function of important membrane proteins. In addition, 2- hydroxyarachidonic acid (2OHARA; LP204A1), 2-hydroxyeicosapentaenoic acid (2OHEPA; LP205A1), and 2-hydroxydocosahexanoic acid (2OHDHA; LP226A1) are new hydroxy derivated lipids designed in our group for the treatment of Alzheimer’s Disease. The main goal of this work was to study how these synthetic hydroxy derivates modulate the unfolded protein response and the autophagy pathways in glioma cells and neuron-like cells for Alzheimer’s Disease.