The Two Faces of JanusUnfolded Protein Response - Autophagy in Cell Death and Survival

  1. Marcilla Etxenike, Amaia
Supervised by:
  1. Pablo Vicente Escribá Ruiz Director
  2. Xavier Busquets Xaubet Director

Defence university: Universitat de les Illes Balears

Fecha de defensa: 30 November 2012

Committee:
  1. Jose Manuel González Ros Chair
  2. José Aurelio Castro Ocón Secretary
  3. Rafel Aguiló Espases Committee member
  4. Arsenio Fernández López Committee member
  5. Luc Leyns Committee member

Type: Thesis

Teseo: 334815 DIALNET lock_openRepositoriUIB editor

Abstract

In this thesis, the pharmacological effects of lipid derivatives against glioma and Alzheimer's Disease are studied. The benefits of this type of drugs, which are based on the lipid membrane therapy, are associated with the modulation of the composition and physicochemical properties of membranes. 2-Hydroxyoleic acid (2OHOA) is a potent antitumor drug designed to regulate membrane lipid composition and structure and the function of important membrane proteins. In addition, 2- hydroxyarachidonic acid (2OHARA; LP204A1), 2-hydroxyeicosapentaenoic acid (2OHEPA; LP205A1), and 2-hydroxydocosahexanoic acid (2OHDHA; LP226A1) are new hydroxy derivated lipids designed in our group for the treatment of Alzheimer’s Disease. The main goal of this work was to study how these synthetic hydroxy derivates modulate the unfolded protein response and the autophagy pathways in glioma cells and neuron-like cells for Alzheimer’s Disease.