The Two Faces of JanusUnfolded Protein Response - Autophagy in Cell Death and Survival

  1. Marcilla Etxenike, Amaia
unter der Leitung von:
  1. Pablo Vicente Escribá Ruiz Doktorvater/Doktormutter
  2. Xavier Busquets Xaubet Doktorvater/Doktormutter

Universität der Verteidigung: Universitat de les Illes Balears

Fecha de defensa: 30 von November von 2012

Gericht:
  1. Jose Manuel González Ros Präsident/in
  2. José Aurelio Castro Ocón Sekretär/in
  3. Rafel Aguiló Espases Vocal
  4. Arsenio Fernández López Vocal
  5. Luc Leyns Vocal

Art: Dissertation

Teseo: 334815 DIALNET lock_openRepositoriUIB editor

Zusammenfassung

In this thesis, the pharmacological effects of lipid derivatives against glioma and Alzheimer's Disease are studied. The benefits of this type of drugs, which are based on the lipid membrane therapy, are associated with the modulation of the composition and physicochemical properties of membranes. 2-Hydroxyoleic acid (2OHOA) is a potent antitumor drug designed to regulate membrane lipid composition and structure and the function of important membrane proteins. In addition, 2- hydroxyarachidonic acid (2OHARA; LP204A1), 2-hydroxyeicosapentaenoic acid (2OHEPA; LP205A1), and 2-hydroxydocosahexanoic acid (2OHDHA; LP226A1) are new hydroxy derivated lipids designed in our group for the treatment of Alzheimer’s Disease. The main goal of this work was to study how these synthetic hydroxy derivates modulate the unfolded protein response and the autophagy pathways in glioma cells and neuron-like cells for Alzheimer’s Disease.