The Two Faces of JanusUnfolded Protein Response - Autophagy in Cell Death and Survival

  1. Marcilla Etxenike, Amaia
Zuzendaria:
  1. Pablo Vicente Escribá Ruiz Zuzendaria
  2. Xavier Busquets Xaubet Zuzendaria

Defentsa unibertsitatea: Universitat de les Illes Balears

Fecha de defensa: 2012(e)ko azaroa-(a)k 30

Epaimahaia:
  1. Jose Manuel González Ros Presidentea
  2. José Aurelio Castro Ocón Idazkaria
  3. Rafel Aguiló Espases Kidea
  4. Arsenio Fernández López Kidea
  5. Luc Leyns Kidea

Mota: Tesia

Teseo: 334815 DIALNET lock_openRepositoriUIB editor

Laburpena

In this thesis, the pharmacological effects of lipid derivatives against glioma and Alzheimer's Disease are studied. The benefits of this type of drugs, which are based on the lipid membrane therapy, are associated with the modulation of the composition and physicochemical properties of membranes. 2-Hydroxyoleic acid (2OHOA) is a potent antitumor drug designed to regulate membrane lipid composition and structure and the function of important membrane proteins. In addition, 2- hydroxyarachidonic acid (2OHARA; LP204A1), 2-hydroxyeicosapentaenoic acid (2OHEPA; LP205A1), and 2-hydroxydocosahexanoic acid (2OHDHA; LP226A1) are new hydroxy derivated lipids designed in our group for the treatment of Alzheimer’s Disease. The main goal of this work was to study how these synthetic hydroxy derivates modulate the unfolded protein response and the autophagy pathways in glioma cells and neuron-like cells for Alzheimer’s Disease.