Publications by the researcher in collaboration with Juan Francisco Martín Martín (32)

2011

  1. A preparative method for the purification of isopenicillin N from genetically blocked Acremonium chrysogenum strain TD189: Studies on the degradation kinetics and storage conditions

    Journal of Antibiotics, Vol. 64, Núm. 6, pp. 447-451

2009

  1. Transcriptional upregulation of four genes of the lysine biosynthetic pathway by homocitrate accumulation in Penicillium chrysogenum: Homocitrate as a sensor of lysine-pathway distress

    Microbiology, Vol. 155, Núm. 12, pp. 3881-3892

2007

  1. Deacetylcephalosporin C Production in Penicillium chrysogenum by Expression of the Isopenicillin N Epimerization, Ring Expansion, and Acetylation Genes

    Chemistry and Biology, Vol. 14, Núm. 3, pp. 329-339

2006

  1. Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase

    Biochemical Journal, Vol. 395, Núm. 1, pp. 147-155

2005

  1. Characterization of the oat1 gene of Penicillium chrysogenum encoding an ω-aminotransferase: Induction by L-lysine, L-ornithine and L-arginine and repression by ammonium

    Molecular Genetics and Genomics, Vol. 274, Núm. 3, pp. 283-294

  2. Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an ω-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the ω-aminotransferase

    Molecular Genetics and Genomics, Vol. 274, Núm. 3, pp. 272-282

  3. Secretion systems for secondary metabolites: How producer cells send out messages of intercellular communication

    Current Opinion in Microbiology, Vol. 8, Núm. 3, pp. 282-293

2004

  1. Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis

    Molecular Genetics and Genomics, Vol. 272, Núm. 5, pp. 562-570

  2. Inactivation of the lys7 Gene, Encoding Saccharopine Reductase in Penicillium chrysogenum, Leads to Accumulation of the Secondary Metabolite Precursors Piperideine-6-Carboxylic Acid and Pipecolic Acid from α-Aminoadipic Acid

    Applied and Environmental Microbiology, Vol. 70, Núm. 2, pp. 1031-1039

  3. Novel genes involved in cephalosporin biosynthesis: the three-component isopenicillin N epimerase system.

    Advances in biochemical engineering/biotechnology, Vol. 88, pp. 91-109

2003

  1. Co-transformation with autonomous replicating and integrative plasmids in Penicillium chrysogenum is highly efficient and leads in some cases to rescue of the intact integrative plasmid

    Fungal Genetics and Biology, Vol. 40, Núm. 2, pp. 83-92

  2. Expression of a synthetic copy of the bovine chymosin gene in Aspergillus awamori from constitutive and pH-regulated promoters and secretion using two different pre-pro sequences

    Biotechnology and Bioengineering, Vol. 83, Núm. 3, pp. 249-259

2002

  1. A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum

    Journal of Biological Chemistry, Vol. 277, Núm. 48, pp. 46216-46225

  2. Subcellular localization of the homocitrate synthase in penicillium chrysogenum

    Molecular Genetics and Genomics, Vol. 266, Núm. 5, pp. 711-719

  3. The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production

    Molecular Genetics and Genomics, Vol. 267, Núm. 5, pp. 673-683

2001

  1. Characterization of the lys2 gene of Acremonium chrysogenum encoding a functional α-aminoadipate activating and reducing enzyme

    Molecular and General Genetics, Vol. 264, Núm. 6, pp. 755-762

  2. Conversion of pipecolic acid into lysine in Penicillium chrysogenum requires pipecolate oxidase and saccharopine reductase: Characterization of the lys7 gene encoding saccharopine reductase

    Journal of Bacteriology, Vol. 183, Núm. 24, pp. 7165-7172

  3. Elicitation of penicillin biosynthesis by alginate in Penicillium chrysogenum, exerted on pcbAB, pcbC, and penDE genes at the transcriptional level

    Journal of Microbiology and Biotechnology, Vol. 11, Núm. 5, pp. 812-818

  4. Intrachromosomal recombination after targeted monocopy integration Penicillium chrysogenum: Stabilization of the direct repeats to prevent loss of the inserted gene

    Current Genetics, Vol. 39, Núm. 4, pp. 231-236

  5. Targeted inactivation of the mecB gene, encoding cystathionine-γ-lyase, shows that the reverse transsulfuration pathway is required for high-level cephalosporin biosynthesis in Acremonium chrysogenum C10 but not for methionine induction of the cephalosporin genes

    Journal of Bacteriology, Vol. 183, Núm. 5, pp. 1765-1772