Publicaciones (66) Publicaciones de JESÚS MANUEL APARICIO FERNÁNDEZ

2022

  1. Modulation of Multiple Gene Clusters’ Expression by the PAS-LuxR Transcriptional Regulator PteF

    Antibiotics, Vol. 11, Núm. 8

  2. Understanding microRNAs in the Context of Infection to Find New Treatments against Human Bacterial Pathogens

    Antibiotics, Vol. 11, Núm. 3

2021

  1. Production, Detection, Extraction, and Quantification of Polyene Antibiotics

    Methods in Molecular Biology (Humana Press Inc.), pp. 333-350

2020

  1. Structural and bioactivity characterization of filipin derivatives from engineered streptomyces filipinensis strains reveals clues for reduced haemolytic action

    Antibiotics, Vol. 9, Núm. 7, pp. 1-11

  2. The Streptomyces filipinensis gamma-butyrolactone system reveals novel clues for understanding the control of secondary metabolism

    Applied and Environmental Microbiology, Vol. 86, Núm. 18

2019

  1. Activation of secondary metabolite gene clusters in streptomyces clavuligerusby the pimm regulator of streptomyces natalensis

    Frontiers in Microbiology, Vol. 10, Núm. MAR

2018

  1. Phosphate effect on filipin production and morphological differentiation in Streptomyces filipinensis and the role of the PhoP transcription factor

    PLoS ONE, Vol. 13, Núm. 12

  2. Promoter engineering reveals the importance of heptameric direct repeats for DNA binding by Streptomyces antibiotic regulatory protein- large ATP-binding regulator of the LuxR family (SARP-LAL) regulators in Streptomyces natalensis

    Applied and Environmental Microbiology, Vol. 84, Núm. 10

2016

  1. Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation

    Applied Microbiology and Biotechnology, Vol. 100, Núm. 1, pp. 61-78

2015

  1. Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives

    Microbial Cell Factories, Vol. 14, Núm. 1

  2. Pathway-specific regulation revisited: cross-regulation of multiple disparate gene clusters by PAS-LuxR transcriptional regulators

    Applied Microbiology and Biotechnology, Vol. 99, Núm. 12, pp. 5123-5135

2014

  1. Erratum to: Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species (Applied Microbiology and Biotechnology DOI: 10.1007/s00253-013-5455-z)

    Applied Microbiology and Biotechnology

  2. Genome-wide analysis of the regulation of pimaricin production in Streptomyces natalensis by reactive oxygen species

    Applied Microbiology and Biotechnology, Vol. 98, Núm. 5, pp. 2231-2241

  3. PAS-LuxR transcriptional control of filipin biosynthesis in S. avermitilis

    Applied Microbiology and Biotechnology, Vol. 98, Núm. 22, pp. 9311-9324

2012

  1. Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506)

    Journal of Bacteriology

  2. Hierarchical control on polyene macrolide biosynthesis: PimR modulates pimaricin production via the PAS-LuxR transcriptional activator pimM

    PLoS ONE, Vol. 7, Núm. 6

  3. LAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolor

    PLoS ONE, Vol. 7, Núm. 2

2011

  1. Functional conservation of PAS-LuxR transcriptional regulators in polyene macrolide biosynthesis

    Metabolic Engineering, Vol. 13, Núm. 6, pp. 756-767

  2. Molecular control of polyene macrolide biosynthesis: Direct binding of the regulator pimm to eight promoters of pimaricin genes and identification of binding boxes

    Journal of Biological Chemistry, Vol. 286, Núm. 11, pp. 9150-9161

2010

  1. Structure of cytochrome P450 PimD suggests epoxidation of the polyene macrolide pimaricin occurs via a hydroperoxoferric intermediate

    Chemistry and Biology, Vol. 17, Núm. 8, pp. 841-851