Acumulación y captación pulmonar de Clorpromazina en el conejo

1. Díez Liébana, María José
2. Sierra Vega, Matilde
3. Terán, M. Teresa
4. García Vieitez, Juan José

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Outras publicacións en: Anales de la Facultad de Veterinaria de León

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We have evaluated the relative contribution of the lung in the in vivo disposition of chlorpromazine in rabbit by determining the extraction pulmonary coefficient. For that, we administered chlorpromazine intra-arterially and intravenously in dosages of 7.5 and 10 mg/kg to rabbits. The extraction pulmonary coefficient was 0.929 and 0.811 for doses of 7.5 and 10 mg /kg respectively. This fact indicates an high uptake of chlorpromazine by rabbit lung.

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