Acumulación y captación pulmonar de Clorpromazina en el conejo

  1. Díez Liébana, María José
  2. Sierra Vega, Matilde
  3. Terán, M. Teresa
  4. García Vieitez, Juan José
Revista:
Anales de la Facultad de Veterinaria de León

ISSN: 0373-1170

Any de publicació: 1991

Any: 37

Número: 37

Pàgines: 105-109

Tipus: Article

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Altres publicacions en: Anales de la Facultad de Veterinaria de León

Resum

We have evaluated the relative contribution of the lung in the in vivo disposition of chlorpromazine in rabbit by determining the extraction pulmonary coefficient. For that, we administered chlorpromazine intra-arterially and intravenously in dosages of 7.5 and 10 mg/kg to rabbits. The extraction pulmonary coefficient was 0.929 and 0.811 for doses of 7.5 and 10 mg /kg respectively. This fact indicates an high uptake of chlorpromazine by rabbit lung.

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