Estudio experimental sobre los efectos de la quercetina en la disfunción orgánica y cognitiva originada por radiación ionizante
- Juan Pablo Barrio Lera
- Raquel Marina Hernández
- Serafín Costilla García
- J.R. Rodríguez
- C. L. Fernández
- María del Carmen Ferreras Estrada
- P. González
ISSN: 1888-6116
Año de publicación: 2013
Volumen: 24
Número: 1
Páginas: 24-32
Tipo: Artículo
Otras publicaciones en: Trauma
Resumen
Objective: To assess the effect of oral quercetin supplementation on the behavioral, biochemical, and histological alterations by a sublethal X-ray dose in rats. Materials and method: Male Wistar rats, supplemented with 50 mg/kg quercetin or solvent, were whole-body irradiated with 6 Gy X-rays. MRI was obtained at 2, 7, 15, and 30 days post-irradiation. Open field exploratory behavior was observed before and after irradiation. Rats were sacrificed at 7 and 30 days post-irradiation, and blood, brain, spinal cord, and bone marrow samples were obtained. Results: Red cell, white cell, and platelet counts strongly decreased at 7 days post-irradiation. White cell and platelet counts recovered at 30 days post-irradiation, with no effect by quercetin. MRI shows focal microbleeds consistent with the histological findings of cell infiltration by neurovascular alterations, more evident in non-supplemented rats. Quercetin improved these changes and reverted the decrease in exploratory activity due to Xirradiation. Conclusions: Preventive use of quercetin could improve early behavioral symptoms and decrease tissue damage appearing shortly after radiotherapy.