Estudio experimental sobre los efectos de la quercetina en la disfunción orgánica y cognitiva originada por radiación ionizante

  1. Juan Pablo Barrio Lera
  2. Raquel Marina Hernández
  3. Serafín Costilla García
  4. J.R. Rodríguez
  5. C. L. Fernández
  6. María del Carmen Ferreras Estrada
  7. P. González
Aldizkaria:
Trauma

ISSN: 1888-6116

Argitalpen urtea: 2013

Alea: 24

Zenbakia: 1

Orrialdeak: 24-32

Mota: Artikulua

Beste argitalpen batzuk: Trauma

Laburpena

Objective: To assess the effect of oral quercetin supplementation on the behavioral, biochemical, and histological alterations by a sublethal X-ray dose in rats. Materials and method: Male Wistar rats, supplemented with 50 mg/kg quercetin or solvent, were whole-body irradiated with 6 Gy X-rays. MRI was obtained at 2, 7, 15, and 30 days post-irradiation. Open field exploratory behavior was observed before and after irradiation. Rats were sacrificed at 7 and 30 days post-irradiation, and blood, brain, spinal cord, and bone marrow samples were obtained. Results: Red cell, white cell, and platelet counts strongly decreased at 7 days post-irradiation. White cell and platelet counts recovered at 30 days post-irradiation, with no effect by quercetin. MRI shows focal microbleeds consistent with the histological findings of cell infiltration by neurovascular alterations, more evident in non-supplemented rats. Quercetin improved these changes and reverted the decrease in exploratory activity due to Xirradiation. Conclusions: Preventive use of quercetin could improve early behavioral symptoms and decrease tissue damage appearing shortly after radiotherapy.