RAFAEL
BALAÑA FOUCE
Catedrático de Universidad
![Foto de Christopher](/img/nophoto.png)
Christopher
Fernández Prada
Publications dans lesquelles il/elle collabore avec Christopher Fernández Prada (16)
2015
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Trypanosomatids see the light: Recent advances in bioimaging research
Drug Discovery Today, Vol. 20, Núm. 1, pp. 114-121
2014
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Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery
International Journal for Parasitology: Drugs and Drug Resistance, Vol. 4, Núm. 3, pp. 326-337
2013
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Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect
Biochemical Pharmacology, Vol. 85, Núm. 10, pp. 1433-1440
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Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB.
PloS one, Vol. 8, Núm. 9
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Synthesis of marine α-methoxylated fatty acid analogs that effectively inhibit the topoisomerase IB from leishmania donovani with a mechanism different from that of camptothecin
Marine Drugs, Vol. 11, Núm. 10, pp. 3661-3675
2012
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2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani
Bioorganic and Medicinal Chemistry Letters, Vol. 22, Núm. 19, pp. 6185-6189
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A pentapeptide signature motif plays a pivotal role in Leishmania DNA topoisomerase IB activity and camptothecin sensitivity
Biochimica et Biophysica Acta - General Subjects, Vol. 1820, Núm. 12, pp. 2062-2071
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Appraisal of a Leishmania major Strain Stably Expressing mCherry Fluorescent Protein for Both In Vitro and In Vivo Studies of Potential Drugs and Vaccine against Cutaneous Leishmaniasis
PLoS Neglected Tropical Diseases, Vol. 6, Núm. 11
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First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme
Pure and Applied Chemistry, Vol. 84, Núm. 9, pp. 1867-1875
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Indotecan (LMP400) and AM13-55: Two novel indenoisoquinolines show potential for treating visceral leishmaniasis
Antimicrobial Agents and Chemotherapy, Vol. 56, Núm. 10, pp. 5264-5270
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Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis
Molecular and Biochemical Parasitology, Vol. 181, Núm. 2, pp. 85-93
2011
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First total synthesis and antileishmanial activity of (Z)-16-methyl-11- heptadecenoic acid, a new marine fatty acid from the sponge Dragmaxia undata
Chemistry and Physics of Lipids, Vol. 164, Núm. 2, pp. 113-117
2010
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DNA topoisomerases in apicomplexan parasites: Promising targets for drug discovery
Proceedings of the Royal Society B: Biological Sciences
2009
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First total synthesis and antiprotozoal activity of (Z)-17-methyl-13-octadecenoic acid, a new marine fatty acid from the sponge Polymastia penicillus
Chemistry and Physics of Lipids, Vol. 161, Núm. 1, pp. 38-43
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Novel findings on trypanosomatid chemotherapy using DNA topoisomerase inhibitors
Mini-Reviews in Medicinal Chemistry, Vol. 9, Núm. 6, pp. 674-686
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Total synthesis and antileishmanial activity of the natural occurring acetylenic fatty acids 6-heptadecynoic acid and 6-icosynoic acid
Lipids, Vol. 44, Núm. 10, pp. 953-961