Características clínicas, anatomopatológicas y moleculares en casos de cáncer colorrectal según localización tumoral y grado de diferenciación

  1. Laura Vilorio-Marqués 1
  2. Antonio José Molina 1
  3. Cristina Diez-Tascón 1
  4. Begoña Álvarez-Cuenllas 1
  5. Concepción Álvarez-Cañas 1
  6. Mercedes Hernando-Martín 1
  7. Tania Fernández-Villa 1
  8. Tomás Elosua 1
  9. Vicente Martín 1
  1. 1 Universidad de León
    info

    Universidad de León

    León, España

    ROR https://ror.org/02tzt0b78

Zeitschrift:
Revista Colombiana de Cancerología

ISSN: 2346-0199,  0123-9015

Datum der Publikation: 2015

Ausgabe: 19

Nummer: 4

Seiten: 193-203

Art: Artikel

DOI: 10.1016/J.RCCAN.2015.06.002 DIALNET GOOGLE SCHOLAR lock_openOpen Access editor

Andere Publikationen in: Revista Colombiana de Cancerología

Zusammenfassung

Aims: Colorectal cancer (CRC) has a high incidence and mortality, with different patterns depending on anatomical location and other pathological characteristics that appear linked to changes in exposure risk factors exposure as well as the diagnosis. All these make it essential to determine the source of the tumour to properly assess the effect of these factors in the development, diagnosis and progression of the disease. The aim was to describe the clinical and anatomical-pathological characteristics of patients diagnosed with CRC in the Health Area of Leon (ASL) based on their location and degree of tumour differentiation. Methods: Information was collected on the clinical and pathological characteristics, including biological markers analysed in clinical routine of 408 patients between 25 and 85 years with a confirmed diagnosis of CRC, and residents in ASL at least six months before diagnosis. Univariate and bivariate analyses were performed according to the degree of differentiation and tumour location. Results: Tumour size decreases from the colon to the rectum from location decline proximal colon to the rectum (Proximal Colon = 5.13cm; Distal Colon = 4.09cm; Rectum = 3.17cm, P< 0.001), with the TNM stage also being higher in proximal areas. Mucinous adenocarcinomas are more frequent in poorly differentiated than in well differentiated tumours (23.1% vs 5.5%). Lymphatic, venous and peri-tumour invasions are more common in poorly differentiated tumours. Conclusions: The distribution in accordance with the location has more advanced TNM stages in the proximal areas, which could be related to the poorer early diagnosis in proximal areas. The association between venous and lymphatic invasion with the degree of differentiation is poorly understood, and requires studies to clarify their possible prognostic interest.

Bibliographische Referenzen

  • (2008). International Agency for Research on Cancer. IARC. Lyon.
  • López-Abente, G,Ardanaz, E,Torrella-Ramos, A,Mateos, A,Delgado-Sanz, C,Chirlaque, MD. (2010). Changes in colorectal cancer incidence and mortality trends in Spain. Ann Oncol. 21. 76-82
  • Naveiro, JC,Peral, A,Díez, AE,González, FA,Burón, JL. (2001). Incidencia y riesgo de cáncer en el área sanitaria de León. Oncología. 24. 21
  • Martín Sánchez, V,Muinelo Voces, MI,Jorquera Plaza, F,Molina De La Torre, AJ,De Abajo Olea, S,Tamames Gómez, S. (2012). Tendencia y distribución municipal de la incidencia de cáncer colorrectal en el área de salud de León (1994-2008). Gastroenterol Hepatol. 35. 299-308
  • Chauvenet, M,Cottet, V,Lepage, C,Jooste, V,Faivre, J,Bouvier, AM. (2011). Trends in colorectal cancer incidence: a period and birth-cohort analysis in a well-defined French population. BMC Cancer. 11. 282
  • Hemminki, K,Santi, I,Weires, M,Thomsen, H,Sundquist, J,Bermejo, JL. (2010). Tumor location and patient characteristics of colon and rectal adenocarcinomas in relation to survival and TNM classes. BMC Cancer. 10. 688
  • Kaemmerer, E,Klaus, C,Jeon, MK,Gassler, N. (2013). Molecular classification of colorectal carcinomas: the genotype-to-phenotype relation. World J Gastroenterol. 19. 8163
  • Sobin, LH. (2003). TNM: evolution and relation to other prognostic factors. Semin Surg Oncol. 21. 3-7
  • Carmona, FJ,Esteller, M. (2010). Epigenomics of human colon cancer. Mutat Res. 693. 53-60
  • Perea, J,Lomas, M,Hidalgo, M. (2011). Molecular basis of colorrectal cancer: towards an individualized management?. Rev Esp Enferm Dig. 103. 29-35
  • (2010). AJCC Colon and rectum.Edge SB, Byrd DR, Compton CC, editores. AJCC Cancer Staging Manual. 7. Springer. New York.
  • Minoo, P,Zlobec, I,Peterson, M,Terraciano, L,Lugli, A. (2010). Characterization of rectal, proximal and distal colon cancers based on clinicopathological, molecular and protein profiles. Int J Oncol. 37. 707
  • Ogino, S,Chan, AT,Fuchs, CS,Giovannucci, E. (2011). Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field. Gut. 60. 397-411
  • Caldarella, A,Crocetti, E,Messerini, L,Paci, E. (2013). Trends in colorectal incidence by anatomic subsite from 1985 to 2005: a populationbased study. Int J Colorectal Dis. 28. 637
  • Thelwell, N,Millington, S,Solinas, A,Booth, J,Brown, T. (2000). Mode of action and application of Scorpion primers to mutation detection. Nucleic Acids Res. 28. 3752
  • Whitcombe, D,Theaker, J,Guy, SP,Brown, T,Little, S. (1999). Detection of PCR products using self-probing amplicons and fluorescence. Nat Biotechnol. 17. 804
  • Zlobec, I,Baker, K,Minoo, P,Hayashi, S,Terracciano, L,Lugli, A. (2009). Tumor border configuration added to TNM staging better stratifies stage II colorectal cancer patients into prognostic subgroups. Cancer. 115. 4021
  • Krzystek-Korpacka, M,Diakowska, D,Grabowski, K,Gamian, A. (2012). Tumor location determines midkine level and its association with the disease progression in colorectal cancer patients: a pilot study. Int J Colorectal Dis. 27. 1319
  • Zlobec, I,Bihl, M,Schwarb, H,Terracciano, L,Lugli, A. (2010). Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis. Int J Cancer. 127. 367
  • Song, W,Wu, SJ,He, YL,Cai, SR,Zhang, CH,Zhang, XH. (2009). Clinicopathological features and survival of patients with colorectal mucinous, signet-ring cell or non-mucinous adenocarcinoma: experience at an institution in southern china. Chin Med. 122. 1486
  • Purim, O,Gordon, N,Brenner, B. (2013). Cancer of the colon and rectum: potential effects of sex-age interactions on incidence and outcome. Med Sci Monit. 19. 203
  • Brenner, H,Hoffmeister, M,Arndt, V,Haug, U. (2007). Gender differences in colorectal cancer: implications for age at initiation of screening. Br J Cancer. 96. 828
  • Jacobs, ET,Thompson, PA,Martinez, ME. (2007). Diet, gender, and colorectal neoplasia. J Clin Gastroenterol. 41. 731
  • Koo, JH,Leong, RW. (2010). Sex differences in epidemiological, clinical and pathological characteristics of colorectal cancer. J Gastroenterol Hepatol. 25. 33-42
  • Chiang, JM,Yeh, CY,Changchien, CR,Chen, JS,Tang, R,Chen, JR. (2010). Mucinous adenocarcinoma showing different clinicopathological features and molecular characteristics in relation to different colorectal cancer subgroups. Int J Colorectal Dis. 25. 941
  • Yamauchi, M,Morikawa, T,Kuchiba, A,Imamura, Y,Qian, ZR,Nishihara, R. (2012). Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut. 61. 847
  • Verhulst, J,Ferdinande, L,Demetter, P,Ceelen, W. (2012). Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis. J Clin Pathol. 65. 381
  • Derwinger, K,Gustavsson, B. (2011). A study of aspects on gender and prognosis in synchronous colorectal cancer. Clin Med Insights Oncol. 5. 259
  • Du, CZ,Xue, WC,Cai, Y,Li, M,Gu, J. (2009). Lymphovascular invasion in rectal cancer following neoadjuvant radiotherapy: a retrospective cohort study. World J Gastroenterol. 15. 3793
  • Andreyev, HJ,Norman, AR,Cunningham, D,Oates, J,Dix, BR,Iacopetta, BJ. (2001). Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer. 85. 692
  • Jenkins, MA,Hayashi, S,O'Shea, AM,Burgart, LJ,Smyrk, TC,Shimizu, D. (2007). Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study. Gastroenterology. 133. 48-56
  • Slattery, ML,Curtin, K,Wolff, RK,Boucher, KM,Sweeney, C,Edwards, S. (2009). A comparison of colon and rectal somatic DNA alterations. Dis Colon Rectum. 52. 1304
Fuente de los datos: Dialnet