El papel de las intervenciones biomédicas en la prevención del VIHla profilaxis preexposición (PrEP)

  1. E.A.M. Zioga 1
  2. J. Arias-de la Torre 2
  3. E. Patera 3
  4. B. Borjabad 4
  5. L. Macorigh 5
  6. L. Ferrer 1
  1. 1 Hospital Dos de Mayo, Barcelona, España
  2. 2 Universidad de León
    info

    Universidad de León

    León, España

    ROR https://ror.org/02tzt0b78

  3. 3 Hospital Comarcal Sant Jaume de Calella, Calella, Barcelona, España
  4. 4 Hospital de Sant Joan Despí Moisès Broggi, Sant Joan Despí, Barcelona, España
  5. 5 Hospital Universitario de Granollers, Granollers, Barcelona, España
Journal:
Semergen: revista española de medicina de familia

ISSN: 1138-3593

Year of publication: 2020

Issue: 3

Pages: 202-207

Type: Article

DOI: 10.1016/J.SEMERG.2019.06.006 DIALNET GOOGLE SCHOLAR

More publications in: Semergen: revista española de medicina de familia

Sustainable development goals

Abstract

La transmisión del VIH sigue siendo un importante problema de salud pública en todo el mundo. Estrategias tradicionales de prevención como la educación sexual, el cribado y el inicio precoz de tratamiento antirretroviral, a pesar de ser efectivas, resultan insuficientes para el control de las nuevas infecciones. En este contexto, se ha propuesto la profilaxis preexposición (PrEP) como estrategia preventiva. Actualmente, se ha demostrado ampliamente que la administración de fármacos antirretrovirales en personas expuestas y no infectadas por VIH puede reducir el riesgo de transmisión sin asociarse a inconvenientes significativos. A pesar de haber demostrado su eficacia para la prevención de nuevas infecciones, la PrEP sigue siendo un tema controvertido, especialmente su coste-efectividad, y no se ha conseguido acceso unánime a los grupos de mayor riesgo de infección. Por ello, y basándonos en la evidencia actual, planteamos que el debate no debería ser si la PrEP es coste-eficaz, sino las posibles repercusiones de implementarla.

Bibliographic References

  • World Health Organization. World Health Statistics. 2017. Monitoring health for the SDGs [portal en Internet]. [consultado 15 Jun 2019]. Disponible en http://www.who.int/gho/publications/world_health_statistics/2017/en/.2017 Google Scholar
  • Dirección General de Salud Pública, Calidad e Innovación. Vigilancia Epidemiológica del VIH y Sida en España 2016. Sistema de Información sobre Nuevos Diagnósticos de VIH. Registro Nacional de Casos de Sida. Plan Nacional sobre el Sida. Madrid; 2017. Google Scholar
  • P. Patel, C. Borkowf, J. Brooks, A. Lasry, A.M.J. Lansky Estimating per-act HIV trasmission risk: a systematic review AIDS., 28 (2014), pp. 1509-1519, 10.1097/QAD.0000000000000298 View Record in ScopusGoogle Scholar
  • WHO. Consolidated guidelines on HIV prevention, diagnosis, treatment and care for key populations. 2016 Update. WHO Guide 2014. Google Scholar
  • J.M. Martín Guerra, M. Martín Asenjo, B. Monteagudo Nogueira, C. Hinojosa Mena-Bernal, C. Rodríguez Martín Reflexiones sobre el infradiagnóstico y la primoinfección por VIH Semergen., 43 (2017), pp. 1-3, 10.1016/j.semerg.2016.10.008 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • V.A. Fonner, S.L. Dalglish, C.E. Kennedy, R. Baggaley, K.R. O’Reilly, F.M. Koechlin, et al. Effectiveness and safety of oral HIV preexposure prophylaxis for all populations AIDS., 30 (2016), pp. 1973-1983, 10.1097/QAD.0000000000001145 View Record in ScopusGoogle Scholar
  • J.G. García-Lerma, M.E. Cong, J. Mitchell, A.S. Youngpairoj, Q. Zheng, S. Masciotra, et al. Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection Sci Transl Med., 2 (2010), p. 14ra4, 10.1126/scitranslmed.3000391 CrossRefGoogle Scholar
  • R.M. Grant, J.R. Lama, P.L. Anderson, V. McMahan, A.Y. Liu, L. Vargas, et al., iPrEx Study Team Preexposure chemoprophylaxis for HIV prevention in men who have sex with men N Engl J Med., 363 (2010), pp. 2587-2599, 10.1056/NEJMoa1011205 View Record in ScopusGoogle Scholar
  • J.M. Baeten, D. Donnell, P. Ndase, N.R. Mugo, J.D. Campbell, J. Wangisi, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women N Engl J Med., 367 (2012), pp. 399-410, 10.1056/NEJMoa1108524 CrossRefView Record in ScopusGoogle Scholar
  • S. McCormack, D.T. Dunn, M. Desai, D.I. Dolling, M. Gafos, R. Gilson, et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): Effectiveness results from the pilot phase of a pragmatic open-label randomised trial Lancet., 387 (2016), pp. 53-60, 10.1016/S0140-6736(15)00056-2 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • J.-M. Molina, C. Capitant, B. Spire, G. Pialoux, L. Cotte, I. Charreau, et al. On-demand preexposure prophylaxis in men at high risk for HIV-1 infection N Engl J Med., 373 (2015), pp. 2237-2246, 10.1056/NEJMoa1506273 CrossRefView Record in ScopusGoogle Scholar
  • M.C. Thigpen, P.M. Kebaabetswe, L.A. Paxton, D.K. Smith, C.E. Rose, T.M. Segolodi, et al. Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana N Engl J Med., 367 (2012), pp. 423-434, 10.1056/NEJMoa1110711 CrossRefView Record in ScopusGoogle Scholar
  • B. Hanscom, H.E. Janes, P.D. Guarino, Y. Huang, E.R. Brown, Y.Q. Chen, et al. Brief report: Preventing HIV-1 infection in women using oral preexposure prophylaxis: A meta-analysis of current evidence J Acquir Immune Defic Syndr., 73 (2016), pp. 606-608, 10.1097/QAI.0000000000001160 View Record in ScopusGoogle Scholar
  • A. Van der Straten, J. Stadler, E. Montgomery, M. Hartmann, B. Magazi, F. Mathebula, et al. Women's experiences with oral and vaginal pre-exposure prophylaxis: The VOICE-C qualitative study in Johannesburg, South Africa PLoS One., 9 (2014), p. e89118, 10.1371/journal.pone.0089118 CrossRefGoogle Scholar
  • A.L. Corneli, K. McKenna, J. Headley, K. Ahmed, J. Odhiambo, J. Skhosana, et al. A descriptive analysis of perceptions of HIV risk and worry about acquiring HIV among FEM-PrEP participants who seroconverted in Bondo, Kenya, and Pretoria, South Africa J Int AIDS Soc., 17 (2014), pp. 1-8, 10.7448/IAS.17.3.19152 Google Scholar
  • L. Van Damme, A. Corneli, K. Ahmed, K. Agot, J. Lombaard, S. Kapiga, et al. Pre-exposure prophylaxis for HIV infection among African women N Engl J Med., 367 (2012), pp. 411-422, 10.1056/NEJMoa1202614 CrossRefView Record in ScopusGoogle Scholar
  • J.M. Marrazzo, G. Ramjee, B.A. Richardson, K. Gomez, N. Mgodi, G. Nair, et al. Tenofovir-based preexposure prophylaxis for HIV infection among African women Obstet Gynecol Surv., 70 (2015), pp. 444-446, 10.1097/01.ogx.0000466878.37011.6f CrossRefView Record in ScopusGoogle Scholar
  • K.B. Patterson, H.A. Prince, E. Kraft, A.J. Jenkins, J. Nicholas, J.F. Rooney, et al. Implications for prevention of HIV-1 transmission Sci Transl Med., 3 (2011), p. 112re4, 10.1126/scitranslmed.3003174 CrossRefGoogle Scholar
  • M. Markowitz, I. Frank, R.M. Grant, K.H. Mayer, R. Elion, D. Goldstein, et al. Safety and tolerability of long-acting cabotegravir injections in HIV-uninfected men (ECLAIR): a multicentre, double-blind, randomised, placebo-controlled, phase 2a trial Lancet HIV., 4 (2017), pp. e331-e340, 10.1016/S2352-3018(17)30068-1 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • A. Nel, N. van Niekerk, S. Kapiga, L.G. Bekker, C. Gama, K. Gill, et al. Safety and efficacy of a dapivirine vaginal ring for HIV prevention in women N Engl J Med., 375 (2016), pp. 2133-2143, 10.1056/NEJMoa1602046 CrossRefView Record in ScopusGoogle Scholar
  • I. Cremin, R. Alsallaq, M. Dybul, P. Piot, G. Garnett, T.B. Hallett The new role of antiretrovirals in combination HIV prevention: A mathematical modelling analysis AIDS., 27 (2013), pp. 447-458, 10.1097/QAD.0b013e32835ca2dd View Record in ScopusGoogle Scholar
  • G.B. Gomez, A. Borquez, K.K. Case, A. Wheelock, A. Vassall, C. Hankins The cost and impact of scaling up pre-exposure prophylaxis for HIV prevention: a systematic review of cost-effectiveness modelling studies PLoS Med., 10 (2013), p. e1001401, 10.1371/journal.pmed.1001401 CrossRefGoogle Scholar
  • Grupo de Estudio de Sida de la SEIMC (GeSIDA). Recomendaciones sobre Profilaxis Pre-Exposición en adultos para la Prevención de la Infección por VIH en España. Google Scholar
  • Plan Nacional Sobre el Sida-Grupo de Expertos PrEP. Documento de consenso. Profilaxis Preexposición al VIH en España. Ministerio de Sanidad, Servicios Sociales e Igualdad; 2018. Google Scholar
  • E.M. Rogers, F. Shoemaker Diffusion of innovation: a cross-cultural approach (1983) Google Scholar
  • S. Cahill, S.W. Taylor, S.A. Elsesser, L. Mena, D. Hickson, M.D. Mayer Stigma, medical mistrust, and perceived racism may affect PrEP awareness and uptake in black compared to white gay and bisexual men in Jackson, Mississippi and Boston, Massachusetts AIDS Care., 29 (2017), pp. 1351-1358, 10.1080/09540121.2017.1300633 CrossRefView Record in ScopusGoogle Scholar
  • R. Goldstein, C.G. Streed, S.R. Cahill Being PrEPared - preexposure prophylaxis and HIV disparities N Engl J Med., 379 (2018), pp. 1293-1295, 10.1056/NEJMp1804306 CrossRefGoogle Scholar
  • E. Ouellet, M. Durand, J.R. Guertin, J. LeLorier, C.L. Tremblay Cost effectiveness of ‘on demand’ Hiv pre-exposure prophylaxis for non-injection drug-using men who have sex with men in Canada Can J Infect Dis Med Microbiol., 26 (2015), pp. 23-29, 10.1155/2015/964512 CrossRefView Record in ScopusGoogle Scholar
  • A. Chen, D.W. Dowdy Clinical effectiveness and cost-effectiveness of HIV pre-exposure prophylaxis in men who have sex with men: Risk calculators for real-world decision-making PLoS One., 9 (2014), p. e108742, 10.1371/journal.pone.0108742 CrossRefGoogle Scholar
  • V. Cambiano, A. Miners, D. Dunn, S. McCormack, K.J. Ong, O.N. Gill, et al. Cost-effectiveness of pre-exposure prophylaxis for HIV prevention in men who have sex with men in the UK: a modelling study and health economic evaluation Lancet Infect Dis., 18 (2018), pp. 85-94, 10.1016/S1473-3099(17)30540-6 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • K.M. Mitchell, A. Lépine, F. Terris-Prestholt, K. Torpey, H. Khamofu, M.O. Folayan, et al. Modelling the impact and cost-effectiveness of combination prevention amongst HIV serodiscordant couples in Nigeria AIDS., 29 (2015), pp. 2035-2044, 10.1097/QAD.0000000000000798 View Record in ScopusGoogle Scholar