Efecto de la ingesta oral de beta-hidroxi-beta-metilbutirato sobre indicadores de daño muscular inducido por una sesión de ejercicio excéntrico en adultos jóvenes físicamente activos

Abstract

β-hydroxy-β-methylbutyrate (HMB) is a leucine metabolite produced from α-ketoisocaproic acid. HMB supplementation has been used as a dietary supplement in sports since 1997, with the aim of decreasing muscle proteolysis. Because of this it has been propose that HMB could improve body composition and decrease muscle damage. The aim of this research was to compare differences between treatments (placebo and HMB) to know differences in body composition and muscle damage variables in recreational sports practitioner having HMB supplementation (3 g / day) or placebo during 6 weeks and after a session of eccentric training. Were determinate before and after HMB supplementation: body composition (DEXA), blood chemistry, lipid profile, and blood count. In addition, before and after an eccentric training session (0, 24, 48 and 72 hours), blood chemistry, lipid profile, oxidative stress, and muscle pain were evaluated. After HMB supplementation there were no changes in body composition), blood chemistry, lipid profile, and blood count. After eccentric training, no differences were observed between groups in muscle pain, blood chemistry, or TBARS. In contrast, significant differences were found in total antioxidant capacity, uric acid concentration, and glutathione peroxidase and superoxide dismutase activities. In conclusion, data obtained suggest that increased antioxidants defenses contribute to the beneficial effects of HMB on oxidative stress.