Xantinuriauna causa rara de urolitiasis en el gato

  1. Javier Del-Ángel-Caraza
  2. Carlos César Pérez-García
  3. Israel Alejandro Quijano-Hernández
  4. Claudia Iveth Mendoza-López
  5. Inmaculada Diez-Prieto
  6. José Simón Martínez-Castañeda
Veterinaria México

ISSN: 0301-5092

Année de publication: 2012

Volumen: 43

Número: 4

Pages: 317-325

Type: Article

D'autres publications dans: Veterinaria México


Xanthinuria is a very rare disease in cats. Its etiology may have a genetic origin or may be due to an iatrogenic xanthine-dehydrogenase inhibition that finally results in urolithiasis. The present work reports two cases of xanthine urolithiasis in European Shorthair unrelated male and female cats. Both uroliths were analyzed by stereoscopic microscopy, infrared spectroscopy and scanning electron microscopy. Besides the report of these two clinical cases, a detailed pathophysiologic review and some updated recommendations for diagnosis and treatment for this condition were done.

Références bibliographiques

  • LEKCHAROENSUK, C, OSBORNE, CA, LULICH, JP. (2001). Epidemiologic study of risk factors for lower urinary tract diseases in cats.. J Am Vet Med Assoc. 218. 1429-1435
  • KRUGER, JM, OSBORNE, CA, GOYAL, SM, WICKSTROM, SL, JOHNSTON, GR, FLETCHER, TF. (1991). Clinical evaluation of cats with lower urinary tract disease. J Am Vet Med Assoc. 199. 211-216
  • RECHE, A, HAGIWARA, MK, MAMIZUKA, E. (1998). Estudo clínico da doenga do trato urinário inferior em gatos domésticos de Sao Paulo. Braz.. J Vet Res Anim Sci. Sao Paulo. 35. 69-74
  • GERBER, B, BORETTI, FS, KLEY, S, LALUHA, P, MÜLLER, C, SIEBER, N. (2005). Evaluation of clinical signs and causes of lower urinary tract disease in European cats. J Small Anim Prac. 46. 571-577
  • BK, SAEVIC, TRANGERUD, C, OTTESEN, N, SORUM, H, EGGERTSDÓTTIR, AV. (2011). Causes of lower urinary tract disease in Norwegian cats. J Fel Med Surg. 13. 410-417
  • CANNON, AB, WESTROPP, JL, RUBY, AL, KASS, PH. (2007). Evaluation of trends in urolith composition in cats: 5,230 cases (1985-2004). J Am Vet Med Assoc. 231. 570-576
  • HOUSTON, DM, MOORE, AEP. (2009). Canine and feline urolithiasis: Examination of over 50000 urolith submissions to the Canadian Veterinary Urolith Centre from 1998 to 2008.. Can Vet J. 50. 1263-1268
  • OSBORNE, CA, LULICH, JP, KRUGER, JM, ULRICH, LK, KOEHLER, LA. (2009). Analysis of 451,891 canine uroliths, feline uroliths, and feline urethral plugs from 1981 to 2007: perspectives from the Minnesota Urolith Center. Vet Clin North Am Small Anim Pract. 39. 183-197
  • HESSE, A, NEIGER, R. (2009). A color handbook of urinary stones in small animal medicine.. Manson-Publishing. London. 105-131
  • OSBORNE, CA, LULICH, JP, LEKCHAROENSUK, C, ALBASAN, A, KOEHLER, LA, CARPENTER, KA. (2003). Feline xanthine urolithiasis: A newly recognized cause of feline lower urinary tract disease. Proceedings of the American College of Veterinary Internal Medicine Forum; 2003 June 4-7. ACVIM Forum. Charlotte. 781-782
  • OSBORNE, CA, LULICH, JP, POLZIN, DJ, SANDERSON, SL, KOEHLER, LA, ULRICH, LK. (1999). Analysis of 77,000 canine uroliths. Vet Clin North Am Small Anim Pract. 29. 17-38
  • OSBORNE, CA, LULICH, JP, SWANSON, LL, ALBASAN, H. (2009). Drug-induced urolithiasis. Vet Clin North Am Small Anim Pract. 39. 55-63
  • LING, GV, RUBY, AL, HARROLD, DR, JOHNSON, DL. (1991). Xanthine-containing urinary calculi in dogs given allopurinol.. J Am Vet Med Assoc. 198. 1935-1940
  • KUCERAJ, BULKOVA, T, RYCHLA, R, JAHN, P. (1997). Bilateral xanthine nephrolithiasis in a dog. J Small Anim Pract. 38. 302-305
  • FLEGEL, T, FREISTADT, R, HAIDER, W. (1998). Xanthine urolithiasis in a Dachshund. Vet Rec. 143. 420-423
  • VAN ZUILEN, NICKEL, RF, VAN DIJK, TH, REJINGOUD, DJ. (1997). Xanthinuria in a family of Cavalier King Charles Spaniels. Vet Q. 19. 172-174
  • WHITE, RN, TICK, NT, WHITE, HL. (1997). Naturally occurring xanthine urolithiasis in a domestic shorthair cat. J Small Anim Pract. 38. 299-301
  • TSUCHIDA, S, KAGI, A, KOYAMA, H, TAGAWA, M. (2007). Xanthine urolithiasis in a cat: a case report and evaluation of candidate gene for xanthine dehydrogenase. J Feline Med Surg. 9. 503-508
  • SHWEIGHAUSER, A, HOWARD, J, MALIK, Y, FRANCEY, T. (2009). Xanthinuria in a domestic shorthair cat. Vet Rec. 164. 91-92
  • MIRANDA, M, RIGUEIRA, L, SUAREZ, ML, CARBAJALES, P, MOURE, P, FIDALGO, LE. (2010). Xanthine Nephrolithiasis in a Galician Blond Beef Calf. J Vet Med Science. 72. 921-923
  • PAIS, VM, LOWE, G, LALLAAS, CD, PREMINGER, GM, ASSIMOS, DG. (2006). Xanthine urolithiasis. Urology. 67. 9-11
  • ARIKYANTS, N, SARKISSIAN, A, HESSE, A, EGGERMANN, LEUMAN, E, STEINMANN, B. (2007). Xanthinuria type 1: a rare cause of urolithiasis. Pediatr Nephrol. 22. 310-314
  • OSBORNE, CA, BARGES, JP, LULICH, JP, ULRICH, L, CARPENTER, K, KOHELER, L. (2004). Feline xanthine urolithiasis: A newly recognized cause of feline lower urinary tract disease. Abstracts of the 10th International Symposium on Urolithiasis; 2004 May 25-28; Hong Kong. Urol Res. 32. 171-172