Análisis de las tasas de letalidad de la infección por SARS-CoV-2 en las comunidades autónomas de España

  1. V. Martín-Sánchez 1
  2. A. Barquilla-García 2
  3. F. Vitelli-Storelli 1
  4. A. Segura-Fragoso 3
  5. A. Ruiz-García 4
  6. A. Serrano-Cumplido 5
  7. V. Olmo-Quintana 5
  8. A. Calderón-Montero 4
  1. 1 Área de Medicina Preventiva y Salud Pública, Universidad de León
  2. 2 EAP de Trujillo, Servicio Extremeño de Salud, Cáceres, España
  3. 3 Servicio de Salud de Castilla-La Mancha (SESCAM)
  4. 4 Servicio Madrileño de Salud (SERMAS)
  5. 5 Servicio Canario de Salud
    info

    Servicio Canario de Salud

    Santa Cruz de Tenerife, España

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Zeitschrift:
Semergen: revista española de medicina de familia

ISSN: 1138-3593

Datum der Publikation: 2020

Titel der Ausgabe: COVID19 en Atención Primaria

Nummer: 1

Seiten: 12-19

Art: Artikel

DOI: 10.1016/J.SEMERG.2020.06.013 DIALNET GOOGLE SCHOLAR

Andere Publikationen in: Semergen: revista española de medicina de familia

Zusammenfassung

Introduction The SARS-CoV-2 pandemic has posed a real challenge to health systems. In Spain, the heterogeneous distribution of the virus infection and the different health strategies have conditioned the morbidity and fatality rate. The aim of this study was to analyse the lethality of the infection by sex and age range in the Autonomous Communities (AC) of Spain. Material and methods To perform the analysis, data were extracted from the Ministry of Health, Regional and Public Health Departments of the different AC. The infected population was estimated from the results of the ENE-COVID19 and the population registered on 1 January 2020 (INE) for the validity of the IgG antibody test with 80% sensitivity and 100% specificity. The case fatality rate (TL) (deaths/1000 estimated infected) by sex and age (< 20 years, 20-64 and ≥ 65 years) was calculated for each AC. The standardized case fatality ratio (REL) was calculated by the exact method (EPIDAT). Results The estimated prevalence of SARS-CoV-2 infection in Spain was 6% (range, 1.4% [Ceuta] - 14.1% [Community of Madrid]). The TL in Spain was 9,6/1000, ranged per AC from 1/1000 in Melilla to 26.6/1000 in La Rioja, with no correlation between case fatality and prevalence of infection. The TL was higher in men (10.2/1000, ratio 1.17 with respect to women), except in Cataluña (ratio 0.92), and especially high in those over 64 years of age in La Rioja (143.5/1000), Asturias (69.2/1000) and Basque Country (46.6/1000). Overall excess REL was found to be over 30% in La Rioja (2.91; 95% CI: 2.36-3.57), Asturias (1.51; 95% CI: 1.27-1.80), Basque Country (1.42; 95% CI: 1.31-1.54) and Extremadura (1.37; 95% CI: 1.20-1.57) and in those over 64 years in Madrid and the Canary Islands. Conclusions SARs-CoV-2 virus infection has been very unevenly distributed in the different ACs, with notably differences in TL between ACs, particularly high in La Rioja, Asturias and the Basque Country. Is important to study the excess in TL the population over 64 years of age in the ACs of Madrid and the Canary Islands.

Bibliographische Referenzen

  • A. Banerjee, L. Pasea, S. Harris, A. González-Izquierdo, A. Torralba, L. Shallcross, et al. Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: Population-based cohort study Lancet., 395 (2020), pp. 1715-1725, 10.1016/S0140-6736(20)30854-0 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • J. Riou, C.L. Althaus Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 Euro Surveill., 25 (2020), p. 2000058, 10.2807/1560-7917.es.2020.25.4.2000058 Google Scholar
  • G. Spiteri, J. Fielding, M. Diercke, C. Campese, V. Enouf, A. Gaymard, et al. First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020 Euro Surveill., 25 (2020), p. 2000178, 10.2807/1560-7917.es.2020.25.9.2000178 Google Scholar
  • A. Oksanen, M. Kaakinen, R. Latikka, I. Savolainen, N. Savela, A. Koivula Regulation and Trust: 3-month follow-up study on COVID-19 mortality in 25 European countries JMIR Public Health Surveill., 6 (2020), p. e19218, 10.2196/19218 CrossRefView Record in ScopusGoogle Scholar
  • C.C. Lai, C.Y. Wang, Y.H. Wang, S.C. Hsueh, W.C. Ko, P.R. Hsueh Global epidemiology of coronavirus disease 2019 (COVID-19): Disease incidence, daily cumulative index mortality, and their association with country healthcare resources and economic status Int J Antimicrob Agents., 55 (2020), p. 105946 https://pubmed.ncbi.nlm.nih.gov/32199877/ ArticleDownload PDFGoogle Scholar
  • Ministerio de Ciencia e Innovación, Ministerio de Sanidad, Consejo Interterritorial del Sistema Nacional de Salud e Instituto de Salud Carlos III. Informe sobre la situación de COVID-19 en España. Informe COVID-19 n.° 30. 11 de May de 2020 [consultado 15 May 2020]. Disponible en: https://www.isciii.es/QueHacemos/Servicios/VigilanciaSaludPublicaRENAVE/EnfermedadesTransmisibles/Documents/INFORMES/Informes%20COVID-19/Informe%20n%C2%BA%2030.%20Situaci%C3%B3n%20de%20COVID-19%20en%20Espa%C3%B1a%20a%2011%20de%20mayo%20de%202020.pdf Google Scholar
  • Pollán M, Pérez-Gómez B, Pastor-Barriuso R, Oteo J, Hernán MA, Pérez-Olmeda M, et al, onbehalf of the ENE-COVID StudyGroup.Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nation wide, population-based seroepidemiological study. Published online July 6, 2020. https://doi.org/10.1016/S0140-6736(20)31483-5 Google Scholar
  • R.A. Middelburg, F.R. Rosendaal COVID-19: How to make between-country comparisons Int J Infect Dis., 96 (2020), pp. 477-481, 10.1016/j.ijid.2020.05.066 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • Ministerio de Ciencia e Innovación, Ministerio de Sanidad, Consejo Interterritorial del Sistema Nacional de Salud e Instituto de Salud Carlos III. Estudio Nacional de sero-Epidemiología de la Infección por SARS-CoV-2 en España (ENE-COVID19) [consultado 7 Jun 2020]. Disponible en: https://portalcne.isciii.es/enecovid19/ Google Scholar
  • Instituto Nacional de Estadística. INEbase. Demografía y población. Cifras de población y Censos demográficos. Cifras de población [consultado 6 Jun 2020]. Disponible en: https://www.ine.es/dyngs/INEbase/es/categoria.htm?c=Estadistica_P&cid=1254734710984 Google Scholar
  • StataCorp. 2017. Stata Statistical Software: Release 15. College Station, TX: StataCorp LLC. Google Scholar
  • Epidat (3.1) [consultado 15 Jun 2020]. Disponible en: https://www.sergas.es/Saude-publica/Documents/1918/Ayuda%20General.pdf Google Scholar
  • Ministerio de Ciencia e Innovación, Ministerio de Sanidad, Consejo Interterritorial del Sistema Nacional de Salud e Instituto de Salud Carlos III. Estudio ENE-COVID19. Segunda Fase. Estudio Nacional de Sero-Epidemiología de la Infección por SARS-CoV-2 en España. Informe Preliminar: 3 de junio de 2020. Disponible en: https://www.mscbs.gob.es/ciudadanos/ene-covid/home.htm Google Scholar
  • H. Salje, C.T. Kiem, N. Lefrancq, N. Courtejoie, P. Bosetti, J. Paireau, et al. Estimating the burden of SARS-CoV-2 in France Science., eabc3517 (2020), 10.1126/science.abc3517 Google Scholar
  • C. Signorelli, T. Scognamiglio, D. Odone COVID-19 in Italy: Impact of containment measures and prevalence estimates of infection in the general population Acta Biomed., 91 (Suppl 3) (2020), pp. 175-179, 10.23750/abm.v91i3-S.9511 View Record in ScopusGoogle Scholar
  • H. Streeck, B. Schulte, B.M. Kümmerer, E. Richter, T. Höller, C. Fuhrmann, et al. Infection fatality rate of SARS-CoV-2 infection in a German community with a super-spreading event Medrvix (2020), 10.1101/2020.05.04.20090076 Google Scholar
  • Stringhini S, Wisniak A, Piumatti G, Azman AS, Lauer SA, Baysson H, et al. Repeated seroprevalence of anti-SARS-CoV-2 IgG antibodies in a population-based simple. https://doi.org/10.1101/2020.05.02.20088898 Google Scholar
  • L.Q. Li, T. Huang, Y.Q. Wang, Z.P. Wang, Y. Liang, T.B. Huang, et al. COVID-19 patients’ clinical characteristics discharge rate, and fatality rate of meta-analysis J Med Virol. (2020), 10.1002/jmv.25757 Google Scholar
  • Rodríguez-Leor O, Cid-Álvarez B, Ojeda S, Martín-Moreiras J, Rumoroso JR, Ramón López-Palop R, et al. Impacto de la pandemia de COVID-19 sobre la actividad asistencial en cardiología intervencionista en España. REC IntervCardiol. 2020;2:82-9 Google Scholar
  • S. Rudilosso, C. Laredo, V. Vera, M. Vargas, A. Renú, L. Llull, et al. Acute stroke care is at risk in the era of COVID-19. Experience at a comprehensive stroke center in Barcelona Stroke. (2020) Published online 2020 May 22. 10.1161/STROKEAHA.120.030329 Google Scholar
  • Instituto de Salud Carlos III. Informe de Vigilancia de la Gripe en España. Temporada 2018-19. Sistema de Vigilancia de la Gripe en España [consultado 15 Jun 2020]. Disponible en: http://vgripe.isciii.es/documentos/20182019/InformesAnuales/Informe_Vigilancia_GRIPE_2018-2019_22julio2019.pdf Google Scholar
  • Ministerio de Sanidad. Centro de Coordinación de Alertas y Emergencias. Actualización n.° 108. Enfermedad por el coronavirus (COVID-19). 17.05.2020 Disponible en: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Actualizacion_108_COVID-19.pdf Google Scholar
  • R. Gupta, A. Misra Contentious issues and evolving concepts in the clinical presentation and management of patients with COVID-19 infection with reference to use of therapeutic and other drugs used in co-morbid diseases (hypertension, diabetes, etc.) Diabetes Metab Syndr., 14 (2020), pp. 251-254, 10.1016/j.dsx.03.012 2020 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • J. Nikolich-Zugich, K.S. Knox, C.F. Rios, B. Natt, D. Bhattacharya, M.J. Fain SARS-CoV-2 and COVID-19 in older adults: What we may expect regarding pathogenesis, immune responses, and outcome GeroScience, 42 (2020), pp. 505-514, 10.1007/s11357-020-00186-0 CrossRefView Record in ScopusGoogle Scholar
  • P.I. Kontou, G.G. Braliou, N.L. Dimou, G. Nikolopoulos, P.G. Bagos Antibody tests in detecting SARS-CoV-2 infection: A meta-analysis Medrvix. (2020), 10.1101/2020.04.22.20074914 Google Scholar
Fuente de los datos: Dialnet