Efecto del tratamiento con candesartan sobre los mecanismos y factores implicados en el desarrollo de la enfermedad cardiovascular asociada a sobrepeso y exceso de tejido adiposo visceral en la rata
- Miana Ortega, María
- Heras Jiménez, Natalia de las
- Martín Fernández, Beatriz
- Ballesteros, Sandra
- Valero, María
- Martínez, Ernesto
- Oubiña, Pilar
- Lahera Juliá, Vicente
- Cachofeiro Ramos, María Victoria
ISSN: 0214-9168, 1578-1879
Year of publication: 2011
Volume: 23
Issue: 2
Pages: 55-61
Type: Article
More publications in: Clínica e investigación en arteriosclerosis
Abstract
Objective: The renin angiotensin system has been shown to participate in the development of metabolic syndrome. The aim of this study was to determine whether the angiotensin ii type 1 receptor blocker, candesartan, exerts a protective effect against metabolic and vascular abnormalities in rats fed a high fat diet (HFD). Methods: Sprague Dawley rats (n = 30) were divided into three groups: 1) rats fed a standard diet for 7 weeks, used as a control group; 2) rats fed a HFD (33.5% fat) for 7 weeks; and 3) rats fed a HFD (33.5% fat) treated with candesartan (2 mg/kg/day) for 7 weeks. Body weight, white and brown adipose tissue weight, plasma concentrations and protein expression of leptin and adiponectin in white adipose tissue, glucose and lipid metabolism were investigated. Results: HFD rats showed increased body, epididymal and lumbar adipose tissue weights. Candesartan attenuated all of these parameters. The leptin/adiponectin ratio of plasma concentrations and protein expression in lumbar adipose tissue increased in HDF rats, and were normalized by candesartan. Candesartan also improved insulin sensitivity and lipid profile. Conclusion: Correction of the leptin-adiponectin imbalance may be an important mechanism participating in the protective effect of candesartan in HDF rats.