The sea lamprey GABAB receptorChanges after spinal cord injury and its role in axonal regeneration

  1. Romaus Sanjurjo, Daniel
Dirigée par:
  1. María Celina Rodicio Directeur/trice
  2. Antón Barreiro Iglesias Co-directeur/trice

Université de défendre: Universidade de Santiago de Compostela

Fecha de defensa: 20 avril 2018

Jury:
  1. Ramon Anadon Vazquez President
  2. Idoia Quintana Urzainqui Secrétaire
  3. Arsenio Fernández López Rapporteur

Type: Thèses

Teseo: 549817 DIALNET lock_openMINERVA editor

Résumé

Spinal cord injury (SCI) causes irreversible loss of function. In contrast to mammals, lampreys show an amazing capacity for spontaneous recovery after a complete SCI. In this study, we analysed the changes in the expression of both gabab subunits after a complete SCI. Our results showed that plastic changes in this system probably contribute to the recovery of function after SCI in lampreys. Pharmacological and genetic manipulations revealed that GABA acting through GABAB receptors promotes axonal regeneration of descending neurons after a complete SCI in lampreys.